import pandas as pd

# Creating a DataFrame
df = pd.DataFrame({'A': [1, 2, 3], 'B': [4, 5, 6], 'C': [7, 8, 9],
      'D': [10, 11, 12]})

# Drop one column and append to a new data frame
df_2 = df.drop(df.columns[[0, 1]], axis=1)

# Print new data frame
print(df_2)

>>>

   C    D
0  7   10
1  8   11
2  9   12