import pandas as pd

# Creating a DataFrame
df = pd.DataFrame({'A': [1, 2, 3], 'B': [4, 5, 6]})

# Renaming a single column
df = df.rename(columns={'A': 'NewA'})

# Print data frame
print(df)

>>>
     NewA  B
0     1    4
1     2    5
2     3    6